RESEARCH PROTOCOL Comparing gastrointestinal motility in clozapine-treated patients before and after laxative
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چکیده
The proposed study is a pre and post treatment study to determine whether commonly used laxative-treatment for clozapine-treated psychiatric inpatients affects gastrointestinal motility (as measured by radiopaque marker (ROM) transit studies). This is a follow up study to the ‘Colonic transit studies to measure gastrointestinal motility in antipsychotic-treated patients’ study described in a previously published research protocol (Every-Palmer et al 2013, available at: http://hdl.handle.net/10523/6070)
منابع مشابه
Clozapine-treated Patients Have Marked Gastrointestinal Hypomotility, the Probable Basis of Life-threatening Gastrointestinal Complications: A Cross Sectional Study.
BACKGROUND Gastrointestinal side effects are particularly common with clozapine and occur with other antipsychotics, ranging from mild constipation to fatal bowel obstruction and/or ischemia. While this adverse-effect spectrum has been attributed to 'gastrointestinal hypomotility', gastrointestinal transit times in antipsychotic-treated patients have not previously been measured, making this me...
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تاریخ انتشار 2016